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Uterine Cancer/ Endometrial Cancer
Cancer of the endometrium involves the inner lining of the womb (uterus) called endometrium.
Another condition with a similar name is called endometriosis. This is a benign condition due to implantation of the endometrial tissue (stroma and glands) in another location like the outside of the uterus or lining of the pelvis during menstruation .
The condition is most common after the age of 60 years. This cancer accounts for about 6 percent of all cancers in women.
Research shows that some women are more at risk of developing the cancer than others. The condition presents as vaginal bleeding. Any post-menopausal women who experiences vaginal bleed should not ignore it. She should immediately seek an appointment with her gynecologist. Sometimes it is first noticed as vaginal spotting after sexual intercourse.
Surgery is the main cornerstone for the treatment of the endometrial cancer. The prognosis of the disease if diagnosed early is extremely good with a five-year survival of over 80%.
The other cancer of the uterus is called sarcoma. These occur rarely and there are several types from low grade or slow growing to high grade that grow more rapidly. The sarcoma usually occur from the muscular wall of the uterus. A benign type is called leiomyoma and the malignant version - leiomyosarcoma. The benign leiomyoma is also called a fibriod tumor. The fibroids are common and usually require no treatment.
The real cause of uterine or endometrial cancer is unknown.
Chronic exposure to estrogen (i.e., a female hormone produced by the ovaries) increases the risk for developing the disease. One of estrogens normal functions is to stimulate the buildup of the endometrial lining of the uterus thereby leading to endometrial hyperplasia which is a precursor for cancer. The following factors increase estrogen exposure -
Early menarche - Menstruating at an early age (beginning menstruation before age 12)
Late menopause (after age 52)- The more years a women has periods, the more exposure of the endometrium to estrogens.
Nulliparity (never having been pregnant)- Pregnancy seems to protect against endometrial cancer. During pregnancy the body produces more progesterone protecting the endometrium by lowering estrogen levels.
Irregular ovulation - Ovulation irregularities have many causes, including obesity and a condition known as Poly Cystic Ovarian Syndrome (PCOS). Irregular ovulation or failure to ovulate can increase the lifetime exposure to estrogen.
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